Tissue-Specific Immunity at the Oral Mucosal Barrier
نویسندگان
چکیده
منابع مشابه
Diversity of antibody-mediated immunity at the mucosal barrier.
Although over 90% of all human infections begin at a mucosal site (respiratory, gastrointestinal, urogenital, or ocular), the total number of infections occurring in the population is relatively low. This is in part the result of the secretion of a complex array of local and systemically produced immunoglobulins (Igs). Since the time of Pasteur (37), when immunization by the oral route was firs...
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Ouellette, Andre J. Mucosal Immunity and Inflammation. IV. Paneth cell antimicrobial peptides and the biology of the mucosal barrier. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G257–G261, 1999.—The hypothesis that epithelial cells release preformed antibiotic peptides as components of mucosal innate immunity has gained experimental support in recent years. In the mammalian small int...
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The mucosal lining of the respiratory and digestive systems contains the largest and most complex immune system in the body, but surprisingly little is known of the immune system that serves the oral mucosa. This review focuses on dendritic cells, particularly powerful arbiters of immunity, in response to antigens of microbial or tumor origin, but also of tolerance to self-antigens and commensa...
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ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2018
ISSN: 1471-4906
DOI: 10.1016/j.it.2017.08.005